abstract：:Retinal melatonin biosynthesis is regulated in part by changes in the activity of serotonin N-acetyltransferase (NAT), which increases at night in dark-adapted retinas, but not in light-exposed retinas. Using an in vitro preparation of Xenopus laevis (African clawed frog) eye cups, we have obtained evidence supporting...

journal_title：Neurochemistry international

authors： Boatright JH,Iuvone PM

更新日期：1989-01-01 00:00:00

abstract：:The possible influence of cholinergic and dopaminergic mechanisms on neurotensin-containing neurones was examined at two different levels; nucleus accumbens and striatum in the rat brain. The acute treatment with the anticholinergic drugs atropine and scopolamine increased neurotensin concentrations in the striatum an...

journal_title：Neurochemistry international

authors： Frey P,Lis M,Coward DM

更新日期：1988-01-01 00:00:00

abstract：:A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

journal_title：Neurochemistry international

authors： Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5-hydroxytryptamine neurons and its ability to undergo autoxidation. The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, which has be...

journal_title：Neurochemistry international

authors： Sinhababu AK,Borchardt RT

更新日期：1988-01-01 00:00:00

abstract：:Human atrial natriuretic peptide (Ser 99-Tyr 126) was rapidly degraded by both choroid plexus and hypothalamic membranes with a complex pattern of cleavage. The use of protease inhibitors allowed a preliminary characterization of the enzymes involved in the hydrolysis of the Ser-Phe and Phe-Arg bonds of iodine-labelle...

journal_title：Neurochemistry international

authors： Deschodt-Lanckman M,Vanneste Y,Michaux F

更新日期：1988-01-01 00:00:00

abstract：:Ethanol (15% v/v) was administered in the drinking water to male Wistar rats over period of 3 months. Binding properties of muscarinic receptors were studied in synaptosomes from selected brain areas using [(3)H]quinuclidinyl benzilate and its displacement by the selective antagonist, pirenzepine and the agonist, carb...

journal_title：Neurochemistry international

authors： Pietzak ER,Wilce PA,Shanley BC

更新日期：1988-01-01 00:00:00

abstract：:We have used an in vitro system to monitor the effects of high levels of ammonia and ethanol on glial cells. Nuclei were isolated and the protein profiles examined by two-dimensional gel electrophoresis. Acute exposure of rat astrocyte cell cultures to ammonia or ethanol resulted in changes in cellular morphology and ...

journal_title：Neurochemistry international

authors： Lipsky RH,Vemuri MC,Silverman SJ

更新日期：1988-01-01 00:00:00

abstract：:It was shown previously that pure oligodendrocytes release proteins when maintained in a chemically defined medium. Among these proteins, a 53 kDa glycoprotein was characterized as a component accessible from the external surface of these glial cells. Specific antibodies directed against this glycoprotein were obtaine...

journal_title：Neurochemistry international

authors： Pari FM,Roussel G,Nussbaum F,Nussbaum JL

更新日期：1988-01-01 00:00:00

abstract：:Choline acetyltransferase activity was detected in extensively washed membranes prepared from rat and guinea pig synaptosomes. When these preparations were treated with the non-ionic detergent Triton X-114 and heated to 37 degrees C to cause phase separation, a significant percentage was found to associate with the de...

journal_title：Neurochemistry international

authors： Docherty M,Bradford HF

更新日期：1988-01-01 00:00:00

abstract：:Transport activity of d-pipecolic acid and of l-pipecolic acid in mouse brain and peripheral tissues were tested, and the effect of immobilization stress was described, along with the method for preparative, enantiomeric resolution and purification of d,l-pipecolic acid using high performance liquid chromatography equ...

journal_title：Neurochemistry international

authors： Nishio H,Sogabe H,Segawa T

更新日期：1988-01-01 00:00:00

abstract：:A novel copper-containing protein has been isolated in electrophoretically homogeneous state from bovine brain extracts. Some physico-chemical properties of the protein are determined (molecular weight, copper content, isoelectric point, amino acid composition, optical and EPR spectra), and they are compared with thos...

journal_title：Neurochemistry international

authors： Mikaelyan MV,Nalbandyan RM

更新日期：1988-01-01 00:00:00

abstract：:Uridine was administered in the drinking water (0.5 mg/ml) in adult 6 month-old rats for 6 months. The mean daily dose of uridine was 12.5 mg/rat. The effects of this treatment on tyrosine hydroxylase, galanin, somatostatin, neuropeptide Y and cholecystokinin-like immunoreactivities were studied by means of semiquanti...

journal_title：Neurochemistry international

authors： Zoli M,Agnat LF,Fuxe K,Cintra A,Grimaldi R,Vanderhaeghen JJ,Eneroth P,Goldstein M

更新日期：1988-01-01 00:00:00

abstract：:Specific binding of [(3)H]d- fenfluramine , an anorectic agent acting on serotonergic system, was characterized in rat total brain minus cerebellum. The binding was reversible, stereospecific and with high affinity (K(d) about 80 nM). The receptor density in total brain was about 32 pmol/g tissue. Subcellular distribu...

journal_title：Neurochemistry international

authors： Mennini T,Gobbi M,Taddei C,Garattini S

更新日期：1988-01-01 00:00:00

abstract：:The effect of GM(1) administration upon the time course of the postlesion changes of [(3)H]5hydroxytryptamine uptake in the partially denervated rat hippocampus has been studied 6, 21, 42 and 90 days after surgery. At 6 and 21 days after operation the postlesion decrease of [(3)H]5-hydroxytryptamine uptake was counter...

journal_title：Neurochemistry international

authors： Kiedrowski L,Gra Dkowska M,Oderfeld-Nowak B

更新日期：1987-01-01 00:00:00

abstract：:Norepinephrine (NE) metabolism in brain regions was studied in the Purkinje cell degeneration (pcd) mutant mouse. The Purkinje cells, which are target cells for noradrenergic (NA) neurons, degenerate completely in the pcd mutant mouse between 17 and 45 days of age, but the NA terminals remain intact. The purpose of th...

journal_title：Neurochemistry international

authors： Ghetti B,Perry KW,Fuller RW

更新日期：1987-01-01 00:00:00

abstract：:High levels of angiotensin converting enzyme (ACE) are found in the caudate-putamen (CPu), globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata; these structures were connected by a continuous band of ACE. In order to investigate whether ACE was associated with dopaminergic projections from the...

journal_title：Neurochemistry international

authors： Chai SY,Christie MJ,Beart PM,Mendelsohn FA

更新日期：1987-01-01 00:00:00

abstract：:Rat brain membranes were incubated with bee venom phospholipase A(2) (PLA(2)) or phospholipase C (PLC) from Clostridium perfringens. PLA(2) caused a significant increase in free polyunsaturated fatty acids concomitant with membrane phospholipid degradation as monitored by HPLC and by gas chromatography. Equal concentr...

journal_title：Neurochemistry international

authors： Chan PH,Chen S,Fishman RA

更新日期：1987-01-01 00:00:00

abstract：:Ependymins are goldfish glycoproteins known to participate in biochemical reactions of memory consolidation after an operant vestibulomotor training-task. The distribution of these proteins was analysed by means of a highly sensitive and specific radioimmunoassay. Ependymins were shown to be characteristic constituent...

journal_title：Neurochemistry international

authors： Schmidt R,Lapp H

更新日期：1987-01-01 00:00:00

abstract：:Neurons with colocalized cholecystokinin and dopamine are present predominantly in the ventral tegmental area and project mainly to the caudal part of the medial nucleus accumbens. The activity of this dopamine system can be evaluated by means of the intracranial self-stimulation behavior on male Wistar rats having ch...

journal_title：Neurochemistry international

authors： De Witte P,Heidbreder C,Roques B,Vanderhaeghen JJ

更新日期：1987-01-01 00:00:00

abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

journal_title：Neurochemistry international

authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

更新日期：1987-01-01 00:00:00

abstract：:The activity of histochemically demonstrable aspartate aminotransferase was measured histophotometrically in the hippocampal formation, in dorsal root ganglia, and in superior cervical ganglia during postnatal development of the rat. The enzyme activity showed a marked (up to 15 times) increase in the dendritic layers...

journal_title：Neurochemistry international

authors： Schmidt W,Wolf G

更新日期：1987-01-01 00:00:00

abstract：:The Mg(2+)-ATPase associated with highly purified cholinergic synaptic vesicles isolated from the Torpedo electric organ can be activated by millimolar concentrations of Ca(2+) only to a maximum of 46%. ATP is hydrolyzed in preference to other tri-nucleotides on Mg(2+)-activation but not on Ca(2+)-activation of the en...

journal_title：Neurochemistry international

authors： Stelzl H,Grondal EJ,Zimmermann H

更新日期：1987-01-01 00:00:00

abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

journal_title：Neurochemistry international

authors： Versace P,Bocchieri P,Marchi M,Raiteri M

更新日期：1987-01-01 00:00:00

abstract：:Tryptophan hydroxylation in cockroach (Periplaneta americana) nervous tissue was measured and compared to the hydroxylation of tryptophan in rat brain. Tryptophan hydroxylation in both tissues requires a pterine cofactor, and is inhibited by p-chlorophenylalanine. The molecular weight of the protein responsible for hy...

journal_title：Neurochemistry international

authors： Sloley BD,Yu PH

更新日期：1987-01-01 00:00:00

abstract：:Dipyridamole (DPR) and nitrobenzylthioinosine (NBI) inhibition of adenosine accumulation in synaptoneurosomes derived from rat cerebral cortex, rat cerebellum, guinea pig cerebral cortex and guinea pig cerebellum was investigated. The inhibition of adenosine accumulation by NBI was observed to be distinctly biphasic i...

journal_title：Neurochemistry international

authors： Morgan PF,Marangos PJ

更新日期：1987-01-01 00:00:00

abstract：:The developmental profiles of the neurotransmitter recognition site, labeled by [(3)H]muscimol, and of the two main modulatory sites, labeled by [(3)H]flunitrazepam and [ (35)S ]t- butylbicyclophosphorothionate , respectively, within the GABA(A) receptor complex, have been determined in chick tectal lobes between embr...

journal_title：Neurochemistry international

authors： Batuecas A,Cubero A,Barat A,Ramírez G

更新日期：1987-01-01 00:00:00

abstract：:The effects of membrane lipid disturbances induced by ischemia and exogenously added lipids on the uptake of GABA and Ca(2+) were investigated in gerbil brain synaptosomes. Ischemia was produced by bilateral ligation of common carotid arteries in Mongolian gerbil for 10 min. The level of the free fatty acids (FFA) inc...

journal_title：Neurochemistry international

authors： Noremberg K,Strosznajder J

更新日期：1986-01-01 00:00:00

abstract：:A number of principles have long guided research into serotonin neurochemistry and some of them are presently reconsidered with a slightly different outlook. An increasing amount of experimental data does not always support these older axioms and as more empirical observations are made, some of these may require modif...

journal_title：Neurochemistry international

authors： Kuhn DM,Wolf WA,Youdim MB

更新日期：1986-01-01 00:00:00

abstract：:The sensitivity of [(3)H]GABA and [(3)H]muscimol high-affinity binding sites to physiological (Krebs-Ringer's bicarbonate) and non-physiological (Tris-citrate) buffers was examined using synaptosomal membranes from bovine retinas. The maximum number of sites (B(max)) for [(3)H]GABA was present when the tissue was assa...

journal_title：Neurochemistry international

authors： Madtes P Jr,Bashir-Elahi R,Chader GJ

更新日期：1986-01-01 00:00:00

abstract：:Using specific antibodies to met-enkephalin, met-enkephalin-Arg(6)-Phe(7) and met-enkephalin-Arg(6)-Gly(7)-Leu(8), we have studied the distribution of these opioid peptides in the frog adrenal gland by means of the indirect immunofluorescence technique. Bright staining of all chromaffin cells was observed by applicati...

journal_title：Neurochemistry international

authors： Leboulenger F,Cupo A,Castanas E,Benyamina M,Pelletier G,Vaudry H

更新日期：1986-01-01 00:00:00

abstract：:A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of 5-hydroxy...

journal_title：Neurochemistry international

authors： Nielsen JA

更新日期：1986-01-01 00:00:00

abstract：:The labelling of gangliosides and sialoglycoproteins (SGP) after injecting intraocularly 30 ?Ci of [(3)H]ManNAc was studied in chickens that had previously received, also intraocularly, 30 or 70 nmol of monensin in 10 ?l of ethanol or 24 ?g of colchicine in 10 ?l saline. Controls received ethanol or saline only. Colch...

journal_title：Neurochemistry international

authors： Nores GA,Caputto R

更新日期：1986-01-01 00:00:00

abstract：:The effects of ?-amino-n-butyric acid (GABA), (+)bicuculline, isoguvacine and 3-(4-chlorophenyl)-4-aminobutyrate [(+/-)baclofen] on the K-induced release of [(3)H]acetylcholine (ACh) were studied in the superior cervical ganglia of the rat in vitro. GABA and isoguvacine inhibited [(3)H]ACh release and these inhibition...

journal_title：Neurochemistry international

authors： Farkas Z,Kása P,Balcar VJ,Joó F,Wolff JR

更新日期：1986-01-01 00:00:00

abstract：:Local excitation of the hippocampus with N- methyl- d,l -aspartic acid caused a rapid release of specific proteins into the extracellular fluid. The proteins were recovered from the effluent of a small implanted tubing, permeable to macromolecules, and analyzed by sodium dodecyl sulphate electrophoresis. ...

journal_title：Neurochemistry international

authors： Nyström B,Hamberger A,Karlsson JO

更新日期：1986-01-01 00:00:00

abstract：:A simple, rapid and sensitive method for the detection of acetylcholine and choline in tissue extracts is reported. Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. The resulting H(2)O(2) produced by choline oxidas...

journal_title：Neurochemistry international

authors： Stadler H,Nesselhut T

更新日期：1986-01-01 00:00:00

abstract：:There were specific changes in the contents of cytoskeletal components and their organization during glioblast differentiation induced by glia maturation factor (GMF). Vimentin and glial fibrillary acidic protein increased in their contents, whereas actin did not. Tubulin was only a minor component of the glial cytosk...

journal_title：Neurochemistry international

authors： Suzuki T,Kato T,Fujii T,Tanaka R

更新日期：1986-01-01 00:00:00

abstract：:An endogenous modulator(s) of the dopamine receptor(s) in bovine and rat brain striatum was detected by demonstrating that water extracts of the striatum inhibited [(3)H]apomorphine binding. This modulator(s) was partially purified by methanol extraction and then successive ion exchange chromatographies on SP-Sephadex...

journal_title：Neurochemistry international

authors： Hirata A,Yamada I,Fujita N,Saito K,Nakahiro M,Yoshida H

更新日期：1986-01-01 00:00:00

abstract：:The effects of subcutaneous (s.c.) oxytocin treatment have been investigated on various parameters of dopaminergic neurotransmission in basal forebrain structures (nucleus olfactorius posterior + nucleus accumbens + septum) of the mouse. Acute oxytocin treatment failed to influence dopamine utilization in the basal fo...

journal_title：Neurochemistry international

authors： Kovács GL,Faludi M,Falkay G,Telegdy G

更新日期：1986-01-01 00:00:00

abstract：:The acylation of myelin proteolipid protein (PLP) and intermediate protein (IP) was investigated in an in vitro system of tissue slices prepared from actively myelinating rat brainstem. The incorporation of [(3)H]palmitate into the proteins in nine subcellular fractions including myelin and other cellular membranes wh...

journal_title：Neurochemistry international

authors： Konat G,Gantt G,Hogan EL

更新日期：1986-01-01 00:00:00

abstract：:The venom secreted from glands appended to the jaws of Glycera convoluta, a Polychaete Annelid, increases the spontaneous quantal release of transmitter from nerve terminals. The component that is biologically active on vertebrate cholinergic nerve terminals has recently been shown to be a high molecular weight protei...

journal_title：Neurochemistry international

authors： Bon C,Saliou B,Thieffry M,Manaranche R

更新日期：1985-01-01 00:00:00